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Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count

When cellular SAM concentrations are low the synthesis of 5-methyltetrahydrofolate by MTHFR will proceed uninhibited, whereas cystathionine -synthase activity will be diminished

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