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The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death

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In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS ( 2 O 2 treatment in both leaves and roots ( Distinct from the positive role of ROS in senescence, NO can both provoke and impede this process, dependent upon its concentration and subcellular location

The compound did not impact food intake, suggesting it works through metabolic enhancement rather than appetite suppression