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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

However, numerous studies have reported that increased intestinal permeability often precedes the onset of T1D-associated symptoms suggesting that disruption of gut barrier integrity may have an aetiological role in T1D or at least contribute to disease pathogenesis (Meddings et al

Clients should be so careful to ensure that they choose an aesthetic practitioner that is able to identify and treat this complication if it arises