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it can reduce H 2 O 2 in the presence of GPx by the reduction of its thiol group and keeps thiol groups from Hb, enzymes and membrane proteins in the reduced form [13], which is very important for the preservation of their functions, once oxidation of these groups can lead to functional and structural cellular modifications

Glutathione enzymes act as built-in defenders against this process

In addition, as an NADPH-dependent coenzyme Q (CoQ) oxidoreductase, apoptosis-inducing factor mitochondria-associated 2 (AIFM2) can use NADPH to catalyse the regeneration of CoQ10 and act synergistically with GPX4 and GSH to inhibit phospholipid peroxidation and ferroptosis [77, 78]

This was also confirmed in an experiment performed on male LIO rats, where tumor incidence depending on Epitalon administration and light exposure was investigated