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Moreover, ROS can impair the epithelial barrier by disrupting the mucus layer, a protective barrier on the intestinal epithelial surface composed of mucins such as MUC2 secreted by IECs

10.1038/s41598-018-19213-4 Sci

Previous work from our group supports the importance of arterial stiffness as an early-stage biomarker for future decrements in brain structure by showing that high levels of arterial stiffness in midlife, but not age-related arterial stiffening, are predictive of lower grey matter volume and greater white matter hyperintensity burden in a 10-year follow-up (Fjell et al., 2014)