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Description

Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg 2+ , spermine, and pH

doi: 10.1038/s41594-017-0011-7 68 RioboNAManningDR

Science 369 , eabc3183 (2020)

[12] Contemporary reporting described the death as a myocardial infarction occurring in a participant who had received the eleventh weekly dose, and the trials attending physician considered the most likely explanation to be pre-existing asymptomatic coronary artery disease rather than the study drug