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Trim7 aggravates ischemic stroke-associated ferroptosis by promoting ubiquitin-mediated degradation of HSPA5

This pathway consists of two enzymes: aldose reductase and sorbitol dehydrogenase ( Figure 1 )

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Negatively charged targets are mainly represented by phospholipids, such as PS, which are secluded in the inner side of the plasmatic membrane in normal cells, but increasing the content of PS and accordingly increasing the cancer cell's negative charge allows for the specificity of ACPs (176,177,178)