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elegans cannot de novo synthesize sterols as they lack genes for squalene synthase and cyclase (34), and they require dietary cholesterol for development (35)

LPS-induced miR-21-3p overexpression increased the protein and mRNA levels of the inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and IL-6 in RPE cells while elevating apoptosis, caspase-3 activity, and levels of cleaved caspase-3 and poly-(ADP-ribose) polymerase proteins, which exacerbate inflammatory responses and apoptosis

The highest stable blood levels are reached at steady state

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