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The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig

In contrast, knockout of miR-221 results in elevated IGF-1 levels and enhances the proliferation of HF-KCs

In addition to a significantly higher rate of tracer leakage (218), tau oligomers and A were found to accumulate in the cerebral vessels of AD model mice (219), and eventually the mice developed cognitive decline

Body mass index in 1.2 million adolescents and risk for end-stage renal disease