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Oral supplements must go through the digestive system, which can limit absorption

WillsABSpauldingABAdjemianJPrevotsDRTurkSPWilliamsCet al

To compensate for the increased effective thickness and reduced contrast at higher tilt angles, we applied tilt-dependent dose weighting, based on a cosine correction model implemented in SerialEM, increasing the total dose per tilt at steeper angles proportionally to the apparent path length of the electron beam through the specimen