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If glutathione levels are low, thats both a reflection of ill health and a cause of ill health, warns Evans

doi: 10.1038/s41590-022-01245-8 87 JahanSBeaconTHXuWDavieJR

Cis -resveratrol is simply the wrong shape to conveniently fit into the SIRT1 binding site and because of this, we do not see the same level of SIRT1 activation