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Current approaches include: Continuous Use Approach: Based on clinical trials that used continuous daily administration for 12-24 weeks without scheduled breaks

Levitt M, Nixon PF, Pincus JH, Bertino JR

From the cardiovascular system: tachycardia, arrhythmia, bradycardia, transverse heart block, cardiac arrest, peripheral vasodilation, collapse, pain in the heart, increased or decreased blood pressure, slowed heart conduction

Managing Cobalt Allergy with Vitamin B12 Needs Strategies for Patients with Cobalt Allergy to Manage Their Vitamin B12 Intake Managing a cobalt allergy while ensuring adequate Vitamin B12 intake requires a strategic approach