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For example, the upregulation of the Nrf2 pathway by lipoic acid in cultured hepatocytes and in the liver of obese or diabetic rats prevented lipid overload-induced steatosis (35) and cell death (36)

In Arabidopsis thaliana ecotype Columbia-0 a 10-nucleotide deletion in the coding region of the HPL (At4g15440) gene results in a truncated HPL without catalytic activity [69]

le 2-[[(2-propynylamino)carbonyl]amino]-N-(2,6-dimthylphnyl)-6-benzothiazolecarboxamide

These observations further confirm the pivotal role of gliT in mediating resistance to gliotoxin, even in fungal species which do not normally contain the gene or biosynthesise gliotoxin