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For example, carriers of the HLA-DRB1 * 01:03 allele (approximately 3% of patients) have a greater than 40% risk of requiring major intestinal surgery within 3 years of diagnosis (Vestergaard et al., 2024)

We also excluded that the IFN-dependent enhancement of neutrophil-derived IL-6 is caused by an induction of TLR7 and its consequent co-activation with TLR8 in response to R848

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