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Our novel NNMT inhibitors display excellent physical chemical properties (e.g., membrane permeability), selectivity, and cellular inhibitory activity against NNMT, concomitantly enhancing the levels of the cofactors SAM and NAD + that independently regulate cellular energy metabolism and epigenetic modifications

Research involving AOD-9604 centers on biochemical and structural analysis, including peptide sequence verification, molecular stability assessment, and investigational modeling of lipid-associated signaling pathways at the molecular level