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Considering their association with many diseases, a large number of studies have investigated the presence and activity of antioxidant enzymes, the presence of their mRNA and deposits or their residual metabolites of OS reactions as indirect biomarkers of diseases (Marcozzi et al., 2003

Role of HO-1 in regulating diabetic cardiomyopathy Diabetic cardiovascular disease is the microvascular and macrovascular disease of the cardiovascular system caused by diabetes, which includes coronary heart disease, diabetic cardiovascular autonomic neuropathy, and diabetic cardiomyopathy [84]