Side effects that may occur soon after allogeneic transplant include: Side effects from chemotherapy or radiation therapy used during conditioning or as part of treatment Infection because of a low white blood cell count (neutropenia) Weakness or fatigue caused by fewer red blood cells (anemia) Increased risk of bleeding or bruising caused by low platelets (thrombocytopenia) Graft failure or rejection if the cells do not grow well or are destroyed Problems with the heart, lung, kidneys, liver, or other organs After the new donor cells have grown, other risks include: Graft-versus-host disease (GVHD) may occur if the donor cells see the patient's normal cells as different and attack them
H (400 MHz, MeOD): 7.927.85 (3 H, m, ArH), 7.847.72 (12 H, m, ArH), 4.77 (1 H, dd, J = 9.5, 4.4 Hz, H-4), 4.04 (1 H, t, J = 6.3 Hz, H-1), 3.90 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.85 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.483.36 (4 H, m, PCH 2 + H-7), 3.323.25 (1 H, m, H-5 A or B partially obscured by residual peaks in NMR solvent), 3.243.15 (2 H, m, H-8), 2.95 (1 H, dd, J = 13.9, 9.5 Hz, H-5 A or B ), 2.58 (2 H, t, J = 7.1 Hz, H-3), 2.312.11 (2 H, m, H-2), 1.781.65 (2 H, m, CH 2 ), 1.651.52 (4 H, m, CH 2 )
ABCG2 function: ABCG2, which is highly expressed on the apical membrane of intestinal epithelial cells, plays a critical role in intestinal urate secretion
The Dutch paper was a reanalysis of the 1977 case of apparent genetic D-lactic acidosis
