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Similarly, depletion of SLC7A11 or GPX4 promotes lipoxygenase-mediated lipid peroxidation and leads to ferroptosis in specific cells or organs (Sato et al., 2005

Hydroxyproline in-depth: In the kidneys and liver, the amino acid hydroxyproline is metabolized in the mitochondria to form pyruvate (used for ATP production) and glyoxylate

The regulator has requested additional pharmacokinetic data

For instance, the efficiency of NC-AA is low due to the non-compatibility of structurally diverse NC-AA with ribosomes and elongation factors ( in vitro including ATP synthesis (Kurihara et al., 2011), PURE protein component self-regeneration (Lavickova, Laohakunakorn, and Maerkl, 2020), and ribosomal components (Jewett et al., 2013)