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Emerging evidence also implicates aberrant Nrf2 activity in psychiatric disorders such as depression, schizophrenia, and bipolar disorder, where redox imbalance and neuroimmune activation disrupt neural function

Food Chem 361:130071

Be it in the form of fatigue, muscle soreness, a lowered immune system, or other manifestations, intense exercise despite its abundant fun and beneficial effects does take a physiological toll