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Additionally, when used in young mice, CAR-T cells were able to persist at considerable levels for up to 12 months post initial treatment and limit the onset of metabolic and physical disorders later in life

Two cytosolic enzymes, GCLC/-GCS (glutamate-cysteine ligase catalytic subunit) and GSS (glutathione synthetase), sequentially catalyze the synthesis of GSH from glycine, cysteine and glutamate in the presence of adenosine 5-triphosphate/ATP (Figure 3) [84]

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