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With the help of proteomics, oxidative modifications to glycolytic enzymes, ATP synthase, -enolase, aconitase (enzyme containing iron-sulfur core), creatine kinase (maintains ATP levels in neurons), and other enzymes have been identified (Butterfield and Boyd-Kimball 2018)

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however, exposure to pro-inflammatory cytokines, such as IL-1 (Monif et al., 2016