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Critical safety thresholds have been established for compounds like EGCG (800 mg/day limit) (240) and -carotene (contraindicated in smokers), while hepatotoxicity cases linked to curcumin formulations have prompted regulatory warnings across multiple jurisdictions

[82] first described its ability to reduce the nitrosyl bond of GSNO instead of carbonyl bonds of its other known substrates

For a better effect on wound healing, it has been observed that topically applied VIC may be more effective for delivery to the skin than orally administered, and there is an increased improvement in tissue regeneration and healing of surgical wounds

10.1186/s12967-020-02452-3 J