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Standard dosing Daily dose: 300-600mcg per day Injection frequency: Once daily, preferably in the morning on an empty stomach Administration route: Subcutaneous injection Most users start at 300mcg to assess tolerance, then increase to 500-600mcg if the lower dose is well-tolerated but results are modest

Patients should be aware that if they suspect any complications with their pain management plan, such as trouble breathing, increased pain or discomfort, or chest pain, they should tell the nurse immediately (1,2,3,19,20)

doi:10.1126/science.867037

Dan, G., MartnezRubio, A., Agewall, S., Boriani, G., Borggrefe, M., Gata, F., Van Gelder, I