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Furthermore, extensive research on BBRs clinical use in humans has established its safety profile, even at higher dosages, in the treatment of various diseases

317 Serum albumin levels decrease with age, 318 possibly increasing A deposition in the brain, as albumin is able to sequester A from the blood

While proper loading time is relatively easily to establish and loading temperature is mostly the temperature used for cell culture (for example 37 C and 39 C for human and mouse cells and cell lines, respectively), additional fine-tuning is needed to establish proper loading concentration of the fluorescent dyes to avoid mitochondrial toxicity, non-specific binding to other cellular structures, photodamage and dye aggregate artifacts

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