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The volume ratio of the eluents A and B, A/B, was changed linearly from 100%/0% to 0%/100% during 0 to 16 min, kept 0%/100% during 16 min to 23 min, and then changed fast linearly from 0%/100% to 100%/0% during the next 1 min

Over time, this damage leads to a gradual decrease in physiological reserves, an increased risk of many diseases, and a general decline in the individuals capacity

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TAR DNA-binding protein 43 (TDP-43) and FUS (fused in sarcoma) Research has identified the cellular protein TDP-43 as an important factor in the cause of ALS, especially the sporadic forms (Mackenzie 2007)