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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

10.1016/j.redox.2022.102272 8 AskewK.LiK.Olmos-AlonsoA.Garcia-MorenoF.LiangY.RichardsonP.et al (2017)

For irreversible inhibitor controls TRi-1 (synthesized in house as reported 45 ), Stattic (Cayman Chemical), and AF (Cayman Chemical), the samples were desalted using a Zeba spin desalting column