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These alterations can result in a release of inflammatory mediators and cytokines with subsequent macrophage activation, polymorphonuclear (PMN) cell recruitment, inflammation, and tissue damage (64)

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Notably, although dietary OBS exhibited linear associations with DKD and low-eGFR ( Figures 2D, E ), it showed a non-linear association with albuminuria ( p for non-linearity = 0.021, p for overall = 0.004)