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Another meta-analysis of 9 randomized controlled trials (RCTs) with 486 patients who compared the vitamin E group with the control group showed a beneficial effect of vitamin E on the incidence and symptoms of CIPN but also proposed that routine prophylactic use of vitamin E is still not recommended [78]

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It is likely that during the process of fermentation by gut microbiota flora, there is an augmentation in the production of phenolic compounds that help increase the bioavailability of the aglycone form of quercetin