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Furthermore, berberine blocks IFN--induced IDO1 expression by inhibiting STAT1 phosphorylation (95)

A clinical review of sUA data from the 0.2, 0.4, and 0.8 mg/kg cohorts revealed that there was no further extension in the duration of uric acid lowering beyond the 0.2 mg/kg pegadricase dose, thus a decision was made to prematurely stop enrollment of subjects in the 1.2 mg/kg group