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292 The interaction between mechanical forces and cellular mechanotransduction mechanisms, such as the integrin-mediated activation of focal adhesion kinase (FAK) and the subsequent activation of the MAPK/ERK pathway, plays a crucial role in ligament adaptation and repair

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[3] The most common causes are: [4] [5] [6] Injury or trauma, including sprains, hematoma Overuse: using a muscle too much, too often, including protecting a separate injury Chronic tension Muscle pain occurs with: Rhabdomyolysis, associated with: Viral infections Compression injury leading to crush syndrome Drug-related Commonly fibrates and statins Occasionally ACE inhibitors, cocaine, and some retroviral drugs Severe potassium deficiency Fibromyalgia EhlersDanlos syndrome Auto-immune disorders, including: Mixed connective tissue disease Systemic lupus erythematosus Polymyalgia rheumatica Polymyositis Dermatomyositis Multiple sclerosis (neurologic pain localised to myotome) Infections, including: Other Overuse [edit] Overuse of a muscle is using it too much, too soon or too often