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doi:10.5021/ad.2016.28.4.438

In contrast, vitamin B12 supplements are most effective when taken on an empty stomachat least two hours after you eat or 30 minutes before your next meal

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As well, some people may have allergies or medical conditions that do not allow them to be a good candidate to receive vitamin B12 shots, such as kidney problems, low potassium levels, deficiencies in other vitamins such as iron or folic acid, or just an allergy or sensitivity to vitamin B12 itself