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Abbreviations 5-FU: 5-Fluorouracil AD: Alzheimer's disease ADDLs: Amyloid-beta-derived diffusible ligands ASOs: Antisense oligonucleotides AuNPs: Gold nanoparticles AuNPsQ: Quantum-sized AuNPs AuNRs: Gold nanorods AuNSs: Gold nanospheres BCA: Bio-barcoding assay cAuNPs: Citrate-capped AuNPs COVID-19: Corona virus disease 2019 CSF: Cerebrospinal fluid CT: Computed tomography CTAB: Cetyltrimethylammonium bromide DABCYL: 4-((4-(Dimethyl-amino)-phenyl)-azo)benzoic acid DAPT: 4,6-Diamino-2-pyrimidinethiol Dox: Doxorubicin EDC: 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide EPR: Enhanced permeability and retention FA: Folate FDA: Food and Drug Administration FITC: Fluorescein isothiocyanate FRET: Fluorescence resonance energy transfer HAuNSs: Hollow AuNSs HF: High-fat HU 1 : Hounsfield unit LFAs: Lateral flow assays LSPR: Localized surface plasmon resonance MDR: Multidrug resistant MGF: Mangiferin MPA: Mercaptopropionic acid MWPLP: Microwave-induced plasma-in-liquid process NCL: Nucleolin NIR: Near-infrared NSMs: Nanostructured materials P

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