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During the conditioned fear extinction procedure, the functional connectivity among the insula, dorsal ACC, vmPFC, hippocampus, amygdala, and thalamus induced by extinction memory recall is impaired in PTSD individuals

However, this study does not establish whether ferroptosis acts upstream in the cascade of oxidative stress, neuroinflammation, and apoptosis, nor does it provide evidence for coupling between impaired astrocytic cystine transport and neuronal ferroptosis

To end this debate, careful consideration based on appropriate experiments performed on animal models is required

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