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Taken together, we propose a model in which increased oxidative stress in TTR-V30M carriers, potentially promoted by misfolded TTR, contributes to reduced GSH availability [49, 50]

At t = 4 h, cells were serum starved and at t = 1 h, pre-treated with vehicle, control IgG1, or L2-Cmu (100 g/mL)

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The recommended starting dose of Sublocade is 300 mg for the first two months, followed by monthly injections of 100 mg as maintenance treatment for as long as you need it.[1] Sublocade can only be administered by a trained professional, as doing it yourself poses a risk of injecting intravenously (into a vein), which can cause serious health problems