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All impact simulations were performed at room temperature for 10 ps using a Berendsen thermostat with a coupling constant of 100 fs and using periodic boundary conditions

Homozygous MRPS7 protein Mitochondrial location: Matrix Mitochondrial Ribosome protein: Small subunit Clinical Onset Congenital Sensorineural deafness Sensorineural deafness Systemic Vomiting Hepatic failure: Hepatomegaly Renal failure Course: More severe sib died in 2nd decade Laboratory Oxidative enzyme deficiencies Liver: Complex I, III & IV Muscle: Borderline changes Serum lactate: High Hypoglycemia Urinary organic acids: 3-hydroxybutyrate peak Muscle Lipid: Increased SDH & COX: Normal Liver: Steatosis

Clin Pharmacokinet (2020) 59(7):84956

Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development