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MMP-responsive particles use peptide sequences cleavable by MMP-2 or MMP-9 to induce size reduction, disassembly or drug release in matrix-rich tumor regions [84], while collagenase or matrix-degrading peptide-loaded platforms aim to lower local collagen or hyaluronan density and reduce interstitial pressure [96]

Calcium entry through the compromised plasma membrane has been shown to activate proteases (calpain, calcineurin), resulting in neurofilament degradation, disruption of axonal transport, and functional failure (Schlaepfer, 1974, 1987)

These biological mechanisms help explain why BPC-157 has become one of the most extensively investigated peptides in soft tissue research

Understanding the role of oxidative stress, including the roles of antioxidants and redox proteins, in COVID-19 infection may help to direct potential therapeutics