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This creates a cystine/cysteine redox cycle across the membrane and creates a reducing extracellular environment that supports cancer cell growth and survival ( Cell Death Ferroptosis is an iron-dependent cell death which is accompanied by iron accumulation and lipid peroxidation

In HepG2 cells PC1 and PC2 explained 73% and 14%, while in MIHA cells, PC1 and PC2 explained 74% and 17% of the variance, respectively ( Supplementary Figure S6A ), supporting a strong and reproducible 8-specific effect in both models