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Histamine Intolerance & DAO Enzyme Deficiency Some individuals with MCAS also have histamine intolerance, meaning their body struggles to break down histamine due to a deficiency in diamine oxidase (DAO), the enzyme responsible for histamine degradation

Avoid injecting into areas of active inflammation, bruising, or tenderness from previous doses

Amplification of genes encoding 1 or more of the ABC drug efflux pumps (P-glycoprotein, MRP1, or ABCG2/BCRP), can also lead to multidrug resistance phenotypes (Cole et al, 1992

Travel-Friendly Precautions Because XERF relies on intentional, deep thermal energy to stimulate collagen, we advise patients not to wash their face with freezing cold water or use heavy ice packs immediately afterward