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Bicarbonate loading (e.g., 0.3 g per kg taken 6090 min prior to exercise or 5 g taken two times per day for 5 days) as sodium bicarbonate has been shown to be an effective way to buffer acidity during high intensity exercise lasting one to 3 min in duration [431, 492,493,494]

This interaction results in the formation of stable complexes with thiol groups in selenium enzymes such as thioredoxin reductase, leading to mercury separation [59,60]

It belongs to the larger class of conjugate additions and results in the mild formation of CC bonds

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