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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Cai W., Haddad M., Haddad R., Kesten I., Hoffman T., Laan R., Westfall S., Defaye M., Abdullah N.S., Wong C., et al

The brain contains the body's second-highest concentration of copper after the liver, where this essential metal serves critical roles in neurotransmitter synthesis, mitochondrial function, and antioxidant defense systems

At the time, the FDA presented a lot of adverse event data that showed there was a risk of immunogenicity immune reactions and that raised some red flags for the committee, said Gupta, an adjunct assistant professor of anesthesiology at the Johns Hopkins University School of Medicine