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The decision was based on results from the Phase 3 TROPION-Breast02 trial, which enrolled 644 patients and compared the TROP2-directed antibody-drug conjugate against investigators choice of chemotherapy in the first-line setting

Decreased BDNF levels in the hippocampus lead to an increase in the frequency of depressive behaviors, with fluctuations observed throughout the progression of the disease (Martinowich et al., 2007)