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The overall RA disease activity score in this study measured by DAS28 was at the lower range and may reflect an effective treat-to-target treatment regime with good access to synthetic and biologic disease modifying anti-rheumatic drugs (respectively s-DMARDs and b-DMARDs)

24 Ruboxistaurin specifically targets the PKC isoform implicated in diabetic microvascular complications, with studies suggesting improved neurologic function in some metrics

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VARSITY TRIAL SECONDARY END POINTS Overall population DIFFERENCES YOU CAN SEE ENTYVIO demonstrated superiority to Humira in endoscopic improvement at Week 52 2 * ENTYVIO IV Humira (adalimumab) CI=confidence interval