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As two negative regulators of p53, MDM2 and MDMX facilitate ferroptosis with or without p53, most likely by altering the lipid profile of cells (Venkatesh et al., 2020), which is confirmed by evidence that with the treatment of MDM2 inhibitor nutlin-3, p53 expression increases and leads to the suppression of X c system inhibitor-induced ferroptosis in HT-1080 cells (Tarangelo et al., 2018)

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1 Introduction Effective lifelong antiretroviral therapy (ART) substantially reduces the incidence of acquired immunodeficiency syndrome (AIDS)-related morbidity and mortality in people living with HIV (PLHIV) and transforms HIV infection into a chronic disease by reducing viraemia to undetectable levels and increasing CD4 + T-cell counts in peripheral blood ( + T-cell reconstitution despite achieving complete suppression of HIV replication

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