When the finely-tuned trafficking of macromolecules is dysregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune disorders can occur.[105] There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases
For example, mutations in the IVD gene encoding the enzyme for leucine degradation cause isovaleric acidemia, in which the intermediate isovaleric acid accumulates and damages the brain and nervous system (Vockley and Ensenauer, 2006)
An experimental study in a murine model INVESTIGATION INTO THERAPEUTIC ROLE OF TRITICUM AESTIVUM (WHEAT) GRASS IN BUSULFAN INDUCE THROMBOCYTOPENIA Pomegranate juice consumption reduces oxidative stress atherogenic modifications to LDL and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice Moderate fish-oil supplementation reverses low-platelet long-chain n-3 polyunsaturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians Role of AntiOxidants in Atherosclerosis: Epidemiological and Clinical Update Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized double-blind crossover placebo-controlled study Plasma platelet factor 4 response in rhesus monkeys fed coconut oil Vitamin K deficiency bleeding presenting as impending brain herniation Severe Thrombocytopenia with Iron Deficiency Anemia Community Experiences Join the conversation and become a part of our empowering community
Diabetologia 55, 457467 10.1007/s00125-011-2334-y [DOI] [PMC free article] [PubMed] [Google Scholar] 88.Madsen, A.B., Knudsen, J.R., Henriquez-Olguin, C., Angin, Y., Zaal, K.J., Sylow, L.et al
