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Beyond primary mitochondrial disorders, in liver mitochondria, MT localizes to the intermembrane space and can be imported into the organelle, where its N-terminal -domain delivers zinc to the electron transport chain, inhibiting respiration in a tissue-specific and zinc-dependent manner

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In some embodiments, the cannabinoid is THC, the cofactor or precursor thereof is niacinamide, the antioxidant is L- ergothioneine, and the mitophagy stimulant is urolithin A