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DOX is not able to transfer through the bloodbrain barrier (BBB), therefore DOX effects against the brain via indirect way [29, 30]

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Goussetis DJ, Altman JK, Glaser H, McNeer JL, Tallman MS, Platanias LC (2010) Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide

titled "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)"