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Two weeks later, still feeling sluggish, I went to see my internist, who gave me a full physical, some homeopathic cures of her own, and an injection of vitamin B12 in my butt

It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

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Typically, the positive effects last from about a week up to a month, though this can vary based on how your body absorbs and utilizes the vitamin, as well as your overall health