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This is particularly relevant given that, while AR inhibitors (e.g., epalrestat) are used to treat diabetic neuropathy in some countries, they have not yet been widely recognized as a definitive therapeutic approach worldwide ( Overall, our findings support the therapeutic potential of AR inhibitors as a targeted pharmacological strategy for polyol pathway-related neuropathies

doi: 10.1016/j.conb.2021.03.003 91 WuD.ChenQ.ChenX.HanF.ChenZ.WangY

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Trend data collection is also important to help determine if the zinc coating is leaching into the system