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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

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10.1016/j.drugalcdep.2007.04.004 40 OkanoM.SatoM.KageyamaS

If motor or non-motor fluctuations determine sleep disturbances, the dopaminergic pharmacotherapy should be adjusted accordingly