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It is unclear whether the risk of bias assessment plan was established prior to the conduct of the review, however, an appropriate risk of bias assessment was used in the final publication and likely did not affect the quality of the review

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Data were recorded with codes only, and unblinding to experimental groups for each sample only occurred once all data had been recorded

It has been shown that FN1 participates in ECM remodeling and its inhibition attenuates fibrosis and improves HF[21]